Contact
    Start Publications Streamlined Fabrication of Hybrid Lipid Bilayer Membranes on ...
    ←  Publication Finder
    QSense

    Streamlined Fabrication of Hybrid Lipid Bilayer Membranes on Titanium Oxide Surfaces: A Comparison of One- and Two-Tail SAM Molecules

    Journal: Nanomaterials, Volume 12, APR

    Authors: Sut, Tun Naw; Tan, Sue Woon; Jeon, Won-Yong; Yoon, Bo Kyeong; Cho, Nam-Joon; Jackman, Joshua A.

    Organizations: National Research Foundation of Korea (NRF) - Korean government (MSIT) [2020R1C1C1004385, 2020R1C1C1005523]; International Research & Development Program of the National Research Foundation of Korea (NRF) - Ministry of Science and ICT [2020K1A3A1A39112724]

    Keywords: hybrid lipid bilayer; self-assembled monolayer; titanium oxide; surface functionalization

    There is broad interest in fabricating cell-membrane-mimicking, hybrid lipid bilayer (HLB) coatings on titanium oxide surfaces for medical implant and drug delivery applications. However, existing fabrication strategies are complex, and there is an outstanding need to develop a streamlined method that can be performed quickly at room temperature. Towards this goal, herein, we characterized the room-temperature deposition kinetics and adlayer properties of one- and two-tail phosphonic acid-functionalized molecules on titanium oxide surfaces in various solvent systems and identified optimal conditions to prepare self-assembled monolayers (SAMs), upon which HLBs could be formed in select cases. Among the molecular candidates, we identified a two-tail molecule that formed a rigidly attached SAM to enable HLB fabrication via vesicle fusion for membrane-based biosensing applications. By contrast, vesicles adsorbed but did not rupture on SAMs composed of one-tail molecules. Our findings support that two-tail phosphonic acid SAMs offer superior capabilities for rapid HLB coating fabrication at room temperature, and these streamlined capabilities could be useful to prepare durable lipid bilayer coatings on titanium-based materials.
    View publication