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    Surface modification of nanodiamond: Toward the dispersion of reinforced phase in poly-L-lactic acid scaffolds

    Year: 2019

    Journal: Int. J. Biol. Macromol., Volume 126, APR 1, page 1116–1124

    Authors: Shuai, Cijun; Li, Yang; Wang, Guoyong; Yang, Wenjing; Peng, Shuping; Feng, Pei

    Organizations: Natural Science Foundation of China [81871494, 51575537, 81572577, 81871498, 51705540]; Hunan Provincial Natural Science Foundation of China [2016JJ1027, 2018JJ3671]; Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme (2018); Open-End Fund for the Valuable and Precision Instruments of Central South University; National Postdoctoral Program for Innovative Talents [BX201700291]; China Postdoctoral Science Foundation [2018M632983]; Project of Hunan Provincial Science and Technology Plan [2017RS3008]; Fundamental Research Funds for the Central Universities of Central South University

    Keywords: Nanodiamond; Phospholipid; Dispersion; Mechanical properties; PLLA scaffolds

    The agglomeration of nanodiamond severely reduces the reinforcement in matrix of composites although it is often used as a reinforcing phase. In this study, nanodiamond was modified by phospholipid to promote its dispersion in Poly-L-lactic acid (PLLA) scaffolds fabricated via selective laser sintering. Concretely, phospholipid was an amphiphilic substance with hydrophilic head and hydrophobic tails. The hydrophilic head could adsorb on nanodiamond surface through hydrogen bonding between the-OH of head and the-COOH of nanodiamond. The hydrophobic tails were forced arrange toward the PLLA matrix. As a result, nanodiamond particles were covered with a layer of phospholipid. They are compelled far away from each other due to the exclusion between the hydrophobic tails. This promoted the dispersion of nanodiamond in PLLA scaffolds. Consequently, the compressive strength, compressive modulus and Vickers hardness of the scaffolds modified by phospholipid increased by 162.8%, 163.2% and 88.2% compared with those of unmodified scaffolds, respectively. Meanwhile, the scaffolds could provide a suitable environment that enabled cells to adhere, grow and migrate, indicating good cytocompatibility. This study suggested the PLLA/nanodiamond scaffolds modified by phospholipid could be a potential candidate for bone tissue engineering applications. (C) 2019 Elsevier B.V. All rights reserved.
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