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    Synthesis and characterization of bile acid-based polymeric micelle as a drug carrier for doxorubicin

    Year: 2021

    Journal: Polym. Adv. Technol., Volume 32, DEC, page 4860–4868

    Authors: Altinkok, Cagatay; Acik, Gokhan; Karabulut, Huseyin Riza Ferhat; Ciftci, Mustafa; Tasdelen, Mehmet Atilla; Dag, Aydan

    Organizations: Trakya University [2018/278]

    Keywords: amphiphilic; drug release; lithocholic acid; photopolymerization

    In the present study, a polymeric micelle based on amphiphilic block copolymer, namely poly(methacrylated methyl lithocholate)-block-poly(oligoethylene glycol methacrylate) (PMML-b-POEGMA) bearing bile acid moiety is prepared via sequential photo-initiated free radical polymerizations, and its drug carrying capacity is investigated using doxorubicin hydrochloride (DOX) as a model drug. For this purpose, two-step procedure is applied in the presence of phenylbis (2,4,6-trimethylbenzoyl)phosphine oxide (BAPO) as bifunctional photo initiator. Based on spectroscopic and chromatographic analyses, the desired amphiphilic block copolymer (PMML-b-POEGMA) is successfully synthesized by wavelength-selective free radical photopolymerization under mild conditions. Finally, the DOX drug is loaded into the PMML-b-POEGMA micelles and then drug release behavior is investigated at two different pH (5.5 and 7.4) values. It is concluded from the results that PMML-b-POEGMA micelles may be used as an efficient nanocarrier to deliver conventional anti-cancer drugs for combination chemotherapy.
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