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    Synthesis and characterization of electrospun cerium-doped bioactive glass/chitosan/polyethylene oxide composite scaffolds for tissue engineering applications

    Year: 2021

    Journal: Ceram. Int., Volume 47, JAN 1, page 260–271

    Authors: Saatchi, Alieza; Arani, Ahmad Razaghian; Moghanian, Amirhossein; Mozafari, Masoud

    Keywords: Bioactive glass; Cerium; Electrospun; Tissue engineering; Scaffold; Regenerative medicine

    In this study, a series of electrospun chitosan/polyethylene oxide (PEO) nanofibrous scaffolds containing dif-ferent amount of cerium-doped bioactive glasses (Ce-BGs) have been fabricated and proposed for tissue engineering applications. On a biological level, higher 8Ce-BG content significantly improved cytocompatibility of the scaffolds. Moreover, results of fibroblast cell culture study showed that greater 8Ce-BG content could enhance cell attachment and cell expansion on fiber mesh. Characterization of the scaffolds revealed that increasing 8Ce-BG content caused bioactive glass nanoparticles to agglomerate at a higher rate. The SEM mapping revealed thorough dispersion of submicrometric clusters in all areas of the polymeric matrix. Contact angle measurements showed that increasing 8Ce-BG/CH ratio from 0 to 10 (wt.%) improved wettability of the scaffold significantly. However, by increasing the ratio beyond 10 (wt.%), the wettability values decreased gradually. In conclusion, it was found that increasing 8Ce-BG/CH weight ratio up to 40 (wt.%) in the scaffold system was practical and useful for soft tissue engineering applications.
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