Contact
    Start Publications Synthesis and Characterization of Magnetic Drug Carriers ...
    ←  Publication Finder
    KSV NIMA

    Synthesis and Characterization of Magnetic Drug Carriers Modified with Tb3+ Ions

    Year: 2022

    Journal: Nanomaterials, Volume 12, MAR

    Authors: Nieciecka, Dorota; Rekorajska, Aleksandra; Cichy, Dariusz; Konska, Paulina; Zuk, Michal; Krysinski, Pawel

    Keywords: magnetic nanoparticles; drug carriers; magnetic hyperthermia; Langmuir monolayers

    The study aimed to synthesize and characterize the magnetic drug carrier modified with terbium (III) ions. The addition of terbium extends the possibilities of their applications for targeted anticancer radiotherapy as well as for imaging techniques using radioisotopes emitting beta(+), beta(-), alpha, and gamma radiation. The synthesis of iron oxide nanoparticles stabilized with citrates using the co-precipitation method (IONP @ CA) was carried out during the experimental work. The obtained nanoparticles were used to synthesize a conjugate containing terbium ions and guanosine-5 '-monophosphate as an analog of drugs from the thiopurine group. Conjugates and their components were characterized using Transmission Electron Microscopy, infrared spectroscopy, X-ray microanalysis, spectrofluorimetry, and thermogravimetric analysis. The hybrid was also investigated with Langmuir layers to check the interaction with analogs of biological membranes.
    View publication