Contact
    Start Publications Synthesis and characterization of silica-chitosan hybrid ...
    ←  Publication Finder
    KSV NIMA

    Synthesis and characterization of silica-chitosan hybrid materials as antibacterial coatings for titanium implants

    Year: 2019

    Journal: Carbohydr. Polym., Volume 203, 1-Jan, page 331–341

    Authors: Palla-Rubio, B.; Araujo-Gomes, N.; Fernandez-Gutierrez, M.; Rojo, L.; Suay, J.; Gurruchaga, M.; Goni, I.

    Organizations: Spanish Ministry of Economy and Competitiveness [MAT2017-86043-R]; University of the Basque Country (UPV/EHU) project [UFI11/56]; Basque GovernmentBasque Government [IT611-13]; Universitat Jaume I [Predoc/2014/25, UJI-B2017-37]; European funding source (ERDF)European Union (EU); European funding source (ESF); [predoc-2016-1-0141]

    Keywords: Chitosan; Antibacterial; Dental implant; Silicon; Sol-gel coatings

    To avoid dental implant-related infections and to promote the osseointegration of titanium implants, the application of silicon and chitosan containing coatings is proposed. Silicon is a well-known osteogenic element and chitosan was selected to confer the antibacterial properties. The synthesis of hybrid silica-chitosan coatings using the sol-gel process is presented and the characterization using Si-29-NMR to verify the correct formation of the network is discussed. The C-13 NMR spectroscopy was used to confirm the covalent union between chitosan and the silicon network. Hydrolytic degradation and silicon release studies showed the effective silicon release from the hybrids and, hence, the possibility to promote bone formation. The introduction of different amounts of chitosan and tetraethyl orthosilicate (TEOS) modulated the Si release. The analysis of cell cultures in vitro demonstrated that the hybrid coatings were not cytotoxic and promoted cell proliferation on their surfaces. The coatings containing 5%-10% chitosan had substantial antibacterial properties.
    View publication