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    Synthesis and supramolecular arrangement of new stearoyl acid-based phenalenone derivatives

    Year: 2021

    Journal: Colloid Surf. A-Physicochem. Eng. Asp., Volume 612, MAR 5

    Authors: Godard, Jeremy; Chapron, David; Bregier, Frederique; Rosilio, Veronique; Sol, Vincent

    Organizations: Region Nouvelle-Aquitaine

    Keywords: Phenalenone-stearoyl acid conjugate; Micelles; Vesicles; Supramolecular chemistry; Self-assembly; CryoTem imaging

    Lipid-based photoantimicrobial supramolecular assemblies are promising structures for the development of new photodynamic treatments of wound bacterial infections. Phenalenone (1H-phenalene-1-one, PN) has been used to obtain four stearoyl acid-based phenalenone derivatives (PNC18), with different types of linkage and different number of acyl chains. After studying the interfacial properties of these compounds, nano-objects were formed with either pure PNC18 or mixtures of PNC18 with 1-stearoyl-2-oleoyl-sn-glycero-3-phosphocholine. Morphologies of these nano-objects were analyzed by CryoTEM imaging. The distearoyl glycerol PN derivative appears promising for building photosensitive micelles or vesicles.
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