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    Synthesis of a mace-like cellulose nanocrystal@Ag nanosystem via in-situ growth for antibacterial activities of poly-L-lactide scaffold

    Year: 2021

    Journal: Carbohydr. Polym., Volume 262, JUN 15

    Authors: Shuai, Cijun; Yuan, Xun; Yang, Wenjing; Peng, Shuping; Qian, Guowen; Zhao, Zhenyu

    Organizations: Natural Science Foundation of China [51935014, 82072084, 81871498]; JiangXi Provincial Natural Science Foundation of China [20192ACB20005, 2020ACB214004, 20202BAB214011]; Provincial Key R&D Projects of Jiangxi [20201BBE51012]; Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme (2018); Project of Hunan Provincial Science and Technology Plan [2017RS3008]; Shenzhen Science and Technology Plan Project [JCYJ20170817112445033]; Innovation Team Project on University of Guangdong Province [2018GKCXTD001]; Technology Innovation Platform Project of Shenzhen Institute of Information Technology 2020 [PT2020E002]

    Keywords: Silver nanoparticles; In-situ growth; Cellulose nanocrystal; Antibacterial properties; Cytocompatibility

    Antibacterial property for scaffolds is an urgent problem to prevent infections in bone repair. Ag nanoparticles possess excellent bactericidal activities, whereas their agglomeration restricts the full play of antibacterial property in scaffold. Herein, a mace-like nanosystem was constructed to improve their dispersion by in-situ growth of Ag nanoparticles on cellulose nanocrystal (CNC), which was labeled CNC@Ag nanosystem. Subsequently, the CNC@Ag nanosystem was introduced into poly-L-lactide (PLLA) scaffolds. Results demonstrated that the nanosystem uniformly dispersed in scaffold. The antibacterial tests demonstrated that the scaffolds possessed robust antibacterial activities against E. coli, with bacterial inhibition rate over 95%. Moreover, ion release behavior corroborated the scaffolds continuously released Ag+ for more than 28 days, which benefited from the immobilization effect of CNC on Ag. Encouragingly, the mechanical properties of the scaffolds were remarkably higher than that of PLLA/CNC scaffolds, owing to the mace-like CNC@Ag nanosystem improved the load transfer efficiency in the scaffold.
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