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    The impact of selected Polycyclic Aromatic Hydrocarbons (PAHs) on the morphology, stability and relaxation of ternary lipid monolayers imitating soil bacteria membrane

    Year: 2019

    Journal: J. Mol. Liq., Volume 276, 1-Feb, page 409–416

    Authors: Hac-Wydro, Katarzyna; Polec, Karolina; Broniatowski, Marcin

    Organizations: National Science Centre [2016/21/B/ST5/00245]

    Keywords: Polycyclic Aromatic Hydrocarbons (PAHs); Langmuir monolayer; Bacteria membrane; Relaxation of the monolayer

    Polycyclic Aromatic Hydrocarbons (PAHs) are the organic compounds of strong human and environmental toxicity. Highly important aspect of cytotoxicity of these substances is related to a direct effect of PAHs on membranes, where they can incorporate and accumulate. The latter is highly problematic also from the point of view of the harmful influence of these compounds on the colony of the soil microorganisms and the negative effect of PAHs on biodegradation processes. Since the exact effect of PAHs on the organisation of lipid membrane is not fully explored, in this work the investigations on the influence of pyrene, tetracene and Naphtho[1,2,3,4-def] chrysene (chrysene) on ternary lipid monolayers imitating gram( + ) Bacillus subtilis soil bacteria were performed. Our intention was to gain insight into the alterations induced by selected PAHs at the level of model bacteria membrane and to discuss the results in the context of PAH toxicity. The experiments involved the surface pressure-area measurements, Brewster Angle Microscopy studies and the analysis of the relaxation of the systems. It was found that PAH molecules tend to be excluded from model membrane, however, they alter its morphology and destabilize the system. Although the mechanism of desorption of the monolayer material depends on the kind of PAH molecule, its concentration is also of great importance. Based on the collected results it can be summarized that the effect of PAH on membrane organisation can be important step in the mechanism of toxicity of these compounds. (C) 2018 Elsevier B.V. All rights reserved.
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