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    The protective effect of Artepillin C against lipid oxidation on model membranes

    Year: 2021

    Journal: J. Mol. Liq., Volume 324, FEB 15

    Authors: Pazin, Wallance Moreira; Marques Ruiz, Gilia Cristine; dos Santos, Marcelo Jose; Benites Aoki, Pedro Henrique; Ito, Amando Siuiti; Leopoldo Constantino, Carlos Jose

    Organizations: INEO; FAPESP [2018/16713-0, 2016/09633-4, 2018/22214-6]; CAPES; CNPq [304100/2018-8, 305771/2016-7]

    Keywords: Green propolis; Artepillin C; Antioxidant activity; Model membranes; Erythrosine

    Brazilian green propolis is awell-known therapeutic product, commonly used in folk medicine. Artepillin C is the major compound of Brazilian green propolis and has received considerable attention owing to its lipophilic affinity and antioxidant activity, enabling the use against lipid oxidation caused by free radicals, which is a first step before degenerative diseases. The protective effect of Artepillin C against lipid oxidation was evaluated here on models of lipid membranes based on Langmuir monolayers and giant unilamellar vesicles (GUVs) formed of 1,2-dioleoyl-sn-glycero-3-phosphocholine DOPC under oxidative stress induced by the photoactivated erythrosin. Our findings show that the lipophilic character of Artepillin C allows the donation of a hydrogen atom of the phenolic hydroxyl group to the lipid radical of both mono and bilayer, avoiding the formation of truncated aldehyde lipids, interrupting oxidative reactions mediated by reactive oxygen species (ROS), therefore playing a role as an antioxidant compound in the lipid environment. The affinity of Artepillin C for lipid structures, together with its antioxidant potential, preclude the lipid peroxidation caused by reactive species. (C) 2020 Elsevier B.V. All rights reserved.
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