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    Water-dispersible, biocompatible and fluorescent poly(ethylene glycol)-grafted cellulose nanocrystals

    Year: 2020

    Journal: Int. J. Biol. Macromol., Volume 153, JUN 15, page 46–54

    Authors: Chu, Youlu; Song, Ruyuan; Zhang, Lei; Dai, Hongqi; Wu, Weibing

    Organizations: Foundation of State Key Laboratory of Biobased Material and Green Papermaking (Qilu University of Technology, Shangdong Academy of Sciences) [KF201804]; Natural Science Foundation of Jiangsu ProvinceNatural Science Foundation of Jiangsu Province [BK20171450]; National Key Research and Development Program of China [2017YFD0601005]; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)

    Keywords: Cellulose nanocrystals; Water dispersibility; Bioimaging

    Fluorescent nanoprobe with good water dispersibility was synthesized by the coupling of fluorescent 1,8-naphthalimide dye (NANI) as well as biocompatible poly (ethylene glycol) (PEG) to cellulose nanocrystals (CNC). FFIR, TGA and XPS analysis confirmed the successful covalent conjugation of NANI and PEG. The rodlike morphology of CNC was generally retained after two-step successive grafting of NANI and PEG. The contact angle and transmittance measurements showed that the grafted PEG brushes improve the hydrophilicity of fluorescent CNC probes and their dispersibility in high-concentration NaCl solutions. The fluorescent CNC probe had good biocompatibility and was successfully used for the bioimaging of Hela cells in physiological environment at high salt concentration. Laser confocal microscopy showed that the fluorescent CNC probe can penetrate the cell membrane and disperse uniformly in the cell with good biocompatibility. The fluorescent CNC probe with nanometer size, strong fluorescence emission and high salt-tolerance possess potential application in biomedical field. (C) 2020 Elsevier B.V. All rights reserved.
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