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    Spontaneous Nanotube Formation of a Very Asymmetric Glycolipid

    Year: 2024

    Authors: Losada Pérez, Patricia; Villanueva, Martin Eduardo; Bar, Laure; Redondo-Morata, Lorena; Namdar, Peter; Ruysschaert, Jean Marie; Pabst, George; Vandier, Christophe; Bouchet, Ana Maria

    Keywords: AFM nanomechanics; high-speed AFM; Langmuir monolayers; lipid nanotubes; membrane thermodynamics; self-assembly

    Over the past decades, advances in lipid nanotechnology have shown that self-assembled lipid structures providing ease of preparation, chemical stability, and biocompatibility represent a landmark on the development of multidisciplinary technologies. Lipid nanotubes (LNTs) are a unique class of lipid self-assembled structures, bearing unique properties such as high-aspect ratio, tunable diameter size, and precise molecular recognition. They can be obtained either by the action of external factors to already formed vesicles or spontaneously, the latter depending strongly on subtle molecular features. Here, we report on the spontaneous formation of supported lipid nanotubes of a particular type of glycolipid, ohmline, whose hydrophobic core displays remarkable asymmetry. The combination of bulk and surface-sensitive techniques indicates that below its main transition, ohmline displays an interdigitated gel phase, likely driven by the unique asymmetry in its hydrophobic core. Enhanced order packing by interdigitation favors the formation of ohmline nanotubes in agreement with chiral-based models of nanotube formation. The findings presented in this work call for additional studies to link lipid molecular structure-assembly relationships, whose understanding is relevant for the controlled design of lipid nanotubes networks in particular and controlled design of soft-matter nanomaterials in general.
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