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    A multitechnique study of preferential protein adsorption on hydrophobic and hydrophilic plasma-modified polymer surfaces

    Year: 2009

    Journal: Colloids and Surfaces B: Biointerfaces, 70 (1), 1 April 2009, Pages 76-83, 20100827

    Authors: Messina G.M.L, Satriano C., Marletta G.

    Last authors: Giovanni Marletta

    Organizations: LAMSUN (Laboratory for Molecular Surfaces and Nanotechnology), Department of Chemical Sciences at University of Catania and CSGI, viale A. Doria 6, – 95125 Catania, Italy

    Country: Italy

    The adsorption process of albumin, lysozyme and lactoferrin was investigated onto polymer surfaces, both hydrophobic and hydrophilic treated by oxygen–plasma. In particular thin films of polyhydroxymethylsiloxane (about 90° of static water contact angle) were converted by oxygen plasma treatments at reduced pressure into hydrophilic SiOx phases (less than 10° of water contact angle). The protein adsorption process was investigated in situ by quartz crystal microbalance with dissipation monitoring in terms of coverage and kinetics mechanism, while chemical structure and topography of the protein adlayers were studied ex situ by angular-resolved XPS and atomic force microscopy, respectively. The plasma surface modification of the polymer film drastically modified the adsorption process of the three proteins, both in terms of kinetics and coverage.