Contact
    Start Publications A polysiloxane surfactant dissolves a poorly soluble drug ...
    ←  Publication Finder
    Attension

    A polysiloxane surfactant dissolves a poorly soluble drug (nystatin) in water

    Year: 2014

    Journal: COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, Vol. 443, p 233-239, 20150722

    Authors: Racles, Carmen; Mares, Mihai; Sacarescu, Liviu

    Organizations: Petru Poni Inst Macromol Chem, Iasi 700487, Romania; Gh Asachi Tech Univ, Dept Nat & Synthet Polymers, Iasi 700050, Romania; Ion Ionescu de la Brad Univ, Lab Antimicrobial Chemotherapy, Iasi 700489, Romania

    The aqueous dissolution of a poorly soluble drug nystatin (Nys) was achieved by a simple, excipient-free procedure using a tromethamol-modified polysiloxane (ST) as surfactant. Long-term stable Nys aqueous formulation was prepared and investigated by different methods, in order to understand the mechanism of drug solubilization. The cryo-TEM analysis revealed the presence of soft vesicles in the Nyst_ST solution. According to TEM measurements, the drug is contained in the hydrophobic layer of the surfactant vesicles. The dynamic light scattering (DLS) measurements on Nys ST showed a main population around 134 nm having the Zeta potential of 33.3 mV. FT-IR, UV-vis, and thermogravimetric (TG-DTG-DTA) data point toward physical encapsulation, accompanied by a decrease of H-bonding between the drug molecules. The antifungal activity tested in vitro toward four yeast strains was seriously improved compared to the aqueous dispersion of the native drug, although the availability was diminished compared to DMSO solution. (C) 2013 Elsevier B.V. All rights reserved.