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    Adsorption of liposomes and emulsions studied with a quartz crystal microbalance

    Year: 2001

    Journal: Advances in Colloid and Interface Science 89-90 (2001) 383-394, 20100827

    Authors: Stalgren J.R., Claesson P.M., Warnheim P.

    Last authors: Torbjorn Warnheim

    Organizations: Department of Chemistry, Surface Chemistry, Royal Institute of Technology, SE-100 44 Stockholm, Sweden Institute for Surface Chemistry, Box 5607, SE-114 86, Stockholm, Sweden Innovation Centre Parenteral Nutrition, Fresenius-Kabi AB, SE-112 87 Stockholm, Sweden

    Country: Sweden

    The adsorption from phospholipid liposome solutions 1.2% and phospholipid stabilized oil-in-water emulsions 20% purified soybean oil with the same phospholipid liposome concentration, has been followed by means of a quartz crystal microbalance allowing the simultaneous determination of changes in resonance frequency and energy dissipation. Both the fundamental resonance frequency and the third overtone were used for following the interfacial processes. The adsorption from the liposome solution resulted in formation of a phospholipid bilayer with an additional and incomplete outer layer of liposomes. The outer layer was removed by dilution leaving a bilayer of phospholipids on the surface. The adsorption process observed from the concentrated emulsion solution was considerably more complex. A slow spreading process that also resulted in some expulsion of material from the interface followed the rapid initial adsorption of emulsion droplets. After rinsing with water a phospholipid bilayer was retained on the surface.