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    Aggregation behaviour of amphiphilic drug and bile salt mixtures at different compositions and temperatures

    Year: 2013

    Journal: Journal of Chemical Thermodynamics, 2013, 64, pp 28-39, 20130926

    Authors: Malik Abdul Rub, Mohmad Shafi Sheikh, Abdullah M. Asiri, Naved Azum, Anish Khan, Aftab Aslam Parwaz Khan, Sher Badahar Khan, Kabir-ud-Din

    Organizations: Chemistry Department, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India

    The micellization and adsorption behaviour of the amphiphilic drug promethazine hydrochloride (PMT – a phenothiazine) and bile salts mixtures were analyzed at different compositions in pure and mixed states in aqueous solutions. By using regular solution theory (RST) and Rosen’s model different physicochemical properties such as critical micellar concentration (cmc), micellar composition, surface excess concentration (Γmax), minimum area per molecule (Amin), interaction parameters (βm, βσ), energetic parameters of micellization as well as other micellar and surface properties have been determined. The values of interaction parameters (β) and activity coefficients f1 and f2 (for both, in mixed monolayer as well as in mixed micelles) indicate the synergistic behaviour. The thermodynamic parameters propose release of water from the hydrophobic portion of the drug at higher temperatures.