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    An Integrated Design, Material, and Fabrication Platform for Engineering Biomechanically and Biologically Functional Soft Tissues

    Year: 2017

    Journal: ACS Appl. Mater. Interfaces, Volume 9, SEP 7, page 29430–29437

    Authors: Bas, Onur; D'Angella, Davide; Baldwin, Jeremy G.; Castro, Nathan J.; Wunner, Felix M.; Saidy, Navid T.; Kollmannsberger, Stefan; Reali, Alessandro; Rank, Ernst; De-Juan-Pardo, Elena M.; Hutmacher, Dietmar W.

    Organizations: Australian Research Council (ITTC in Additive Biomanufacturing); National Health and Medical Research Council (NHMRC) [1082313]; National Breast Cancer Foundation [NBCF IN-15-047]; Worldwide Cancer Research [WWCR 15-11563]; TUM Institute for Advanced Study; German Excellence Initiative; European Union [291763]; German Research Foundation (DFG) [RA 624/22, RA 624/27, SPP 1748]

    Keywords: biomimetic; soft network composite; tissue engineering; hydrogel; 3D printing; fiber reinforcement; melt electrospinning writing; interpenetrating polymer network

    We present a design rationale for stretchable soft network composites for engineering tissues that predominantly function under high tensile loads. The convergence of 3D-printed fibers selected from a design library and biodegradable interpenetrating polymer networks (IPNs) result in biomimetic tissue engineered constructs (bTECs) with fully tunable properties that can match specific tissue requirements. We present our technology platform using an exemplary soft network composite model that is characterized to be flexible, yet similar to 125 times stronger (E = 3.19 MPa) and similar to 100 times tougher (W-Ext = similar to 2000 kJ m(-3)) than its hydrogel counterpart.
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