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    An Investigation of the Mechanisms of Electronic Sensing of Protein Adsorption on Carbon Nanotube Devices

    Year: 2004

    Journal: J. Am. Chem. Soc. 2004 126(5) 1563-1568, 20100827

    Authors: Chen R.J., Choi H.C., Bangsaruntip S., Yenilmez E., Tang X., Wang Q., Chang Y-L., Dai H.

    Last authors: Hongjie Dai

    Organizations: Department of Chemistry, Stanford University, Stanford, California 94305, and Agilent Laboratories, Agilent Technologies, Inc., 3500 Deer Creek Road, Palo Alto, California 94304

    Country: USA, US, United States of America

    It has been reported that protein adsorption on single-walled carbon nanotube field effect transistors (FETs) leads to appreciable changes in the electrical conductance of the devices, a phenomenon that can be exploited for label-free detection of biomolecules with a high potential for miniaturization. This work presents an elucidation of the electronic biosensing mechanisms with a newly developed microarray of nanotube "micromat" sensors. Chemical functionalization schemes are devised to block selected components of the devices from protein adsorption, self-assembled monolayers (SAMs) of methoxy(poly(ethylene glycol))thiol (mPEG-SH) on the metal electrodes (Au, Pd) and PEG-containing surfactants on the nanotubes. Extensive characterization reveals that electronic effects occurring at the metal-nanotube contacts due to protein adsorption constitute a more significant contribution to the electronic biosensing signal than adsorption solely along the exposed lengths of the nanotubes.