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    Antibacterial oil-based polyurethane films for wound dressing applications

    Year: 2010

    Journal: Journal of Applied Polymer Science, Volume 115, Issue 3, pages 1347–1357, 5 February 2010, 20111221

    Authors: Ferhat Yücedag, 1, Cigdem Atalay-Oral, 1, Sibel Erkal, 2, Ahmet Sirkecioglu, 1, Djursun Karasartova, 3, Fikret Sahin, 3, Serife Birgül Tantekin-Ersolmaz, 1, Fatma Seniha Güner, 1

    Organizations: 1 Department of Chemical Engineering, Istanbul Technical University, Maslak, Istanbul 34469 Turkey ,2 Faculty of Health Sciences, Midwifery Department, Ankara University, Altindag, Ankara, Turkey, 3 Faculty of Medicine, Microbiology and Clinical Microbiology, Ankara University, Ankara 06100 Turkey

    As an alternative to petroleum-based polyol, hydroxyl containing material was prepared from linseed oil for polyurethane synthesis. Hexamethylene di-isocyanate (HMDI) and/or 4, 4′-methylene diphenyl di-isocyanate (MDI) were used as isocyanate source. The polymerization reaction was carried out without catalyst. Polymer films were prepared by casting-evaporation technique. The MDI/HMDI-based polyurethane and its films had higher Tg and better thermal property than that of the HMDI-based one because of the existence of benzene ring in the polymer chain. Static water contact angle was determined to be 74° and 77.5° for HMDI and MDI/HMDI-based films, respectively. Water adsorption was found to be around 2.6–3.6% for both films. In vitro degradation of polyurethanes in phosphate buffered saline at 37°C was investigated by gravimetric method. Fourier transform infrared spectroscopy and scanning electron microscopy were used for confirmation of degradation on the polymer surface. The degradation rate of the HMDI-based polyurethane film was found higher than that of the MDI/HMDI-based film. Both the direct contact method and the MMT test were applied for determination of cytotoxicity of polymer films, and the polyurethane films investigated here was not cytotoxic. Silver-containing films were prepared using Biocera A® as filler and were screened for their antibacterial performance against Escherichia coli, Pseudomonas aeruginosa,Staphylococcus aureus, and/or Bacillus subtilis. The films prepared with and without Biocera A® exhibited antibacterial activity.