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    Antifungal bionanocomposites based on poly(lactic acid) and silver nanoparticles for potential medical devices

    Year: 2015

    Journal: ROMANIAN BIOTECHNOLOGICAL LETTERS, Vol. 20, p 10696-10707, 20170208

    Authors: Stoica, Petruta; Rapa, Maria; Chifiriuc, Mariana-Carmen; Lungu, Maria; Tatia, Rodica; Nita, Mihaita Iulian; Grumezescu, Alexandru Mihai; Bertesteanu, Serban; Bezirtzoglou, Eugenia; Lazar, Veronica

    Organizations: SC ICPE BISTRITA SA, Bistrita 420035, Romania; Univ Bucharest, Fac Biol, Dept Microbiol, Bucharest, Romania; Univ Bucharest, Res Inst, Life, Environm & Earth Sci, Bucharest, Romania; Natl Inst Res & Dev Biol Sci, Bucharest 060031, Romania; Univ Politehn Bucuresti, Dept Chem Engn, Fac Appl Chem & Mat Sci, Bucharest 011061, Romania; Univ Politehn Bucuresti, Dept Sci & Engn Oxide Mat & Nanomat, Fac Appl Chem & Mat Sci, Bucharest 011061, Romania; Coltea Clin Hosp, Head & Neck Surg Clin, Bucharest, Romania; Univ Med & Pharm Carol Davila, Bucharest, Romania; Democritus Univ Thrace, Fac Agr Dev, Dept Food Sci & Technol, Lab Microbiol Biotechnol & Hyg, Orestiada 68200, Greece

    Novel biocompatible and antimicrobial composites based on poly(lactic acid) (PLA), hydrolyzed collagen (HC) and silver nanoparticles (AgNPs) were prepared by melt processing. Tributyl o-acetyl citrate (ATBC) was used as plasticizer, for improving the processability of PLA. The influence of HC and AgNPs on the PLA bionanocomposites was investigated in terms of biocompatibility, antifungal activity and water contact angle measurements. Surface morphology by SEM and the identification of AgNPs by UV-Vis were also presented. The investigated bionanocomposites exhibited the characteristic plasmonic effect of silver nanoparticles. All composites showed a high degree of biocompatibility. Sample containing HC 5 wt.% and AgNPs showed a significant antifungal property, inhibiting fungal adhesion and mature biofilm development. The increased hydrophilicity determined by contact angle analysis for the PLA/HC10/AgNPs composite did no contributed significantly to improving of anti-adherence effect. 10 wt.% HC promoted fungal colonization and mature biofilm development.