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    Antimicrobial activity of aurein 2.5 against yeasts

    Year: 2013

    Journal: FEMS MICROBIOLOGY LETTERS, Vol. 346, p 140-145, 20150703

    Authors: Dennison, Sarah R.; Harris, Frederick; Morton, Leslie H. G.; Phoenix, David A.

    Organizations: Univ Cent Lancashire, Sch Pharm & Biomed Sci, Preston PR1 2HE, Lancs, England; Univ Cent Lancashire, Sch Forens & Invest Sci, Preston PR1 2HE, Lancs, England

    Fungal infections with multiple resistance to conventional antifungals are increasingly becoming a medical problem, and there is an urgent need for new antifungal compounds with novel mechanisms of action. Here, we show that aurein 2.5, a naturally occurring peptide antibiotic, displays activity against the fungal strains: Rhodotorula rubra and Schizosaccharomyces pombe (MICs <130M). The peptide adopted high levels of membrane-interactive -helical structure (>65%) in the presence of lipid membranes derived from these organisms and showed strong propensities to penetrate (13mNm(-1)) and lyse them (>70%). Based on these data, we suggest that aurein 2.5 kills yeasts via membranolytic mechanisms and may act as a template for the development of therapeutically useful antifungal agents.