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    Basic and enzymatic hydrolysis in mixed polyethylene glycol/poly(D,L-lactide-co-glycolide) films spread at the air-water interface

    Year: 2002

    Journal: Colloids and Surfaces B: Biointerfaces 23 (2002) 7-21, 20111221

    Authors: Tz. Ivanova , P. Saulnier , A. Malzert , F. Boury , J.E. Proust , I. Panaiotov

    Organizations: a Biophysical Chemistry Laboratory, Faculty of Chemistry, University of Sofia, J. Bourchier str. 1, 1126 Sofia, Bulgaria b Unite de Vectorisation Particulaire, UPRES EA 2169, Faculte de Pharmacie, 16 Bd Daviers, 49100 Angers, France

    The role of the polyethylene glycol (PEG) on the mechanisms of hydrolysis of poly(D,L-lactide-co-glycolide) (PLAGA) in mixed monolayers at alkaline pH and under the enzymatic action of cutinase was studied by use of a Langmuir balance. The obtained decreases in the surface area at constant surface pressure are interpreted as a result of solubilization of PEG and the progressively obtained small soluble fragments of PLAGA during the interfacial hydrolysis. In the framework of the random scission mode of fragmentation, the values for the degree of completion of the hydrolysis and specific activity of enzyme were obtained numerically. A small surface dilution effect of the PEG in respect to the degradable polyester molecules PLAGA in their mixed monolayers was found.