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    Biocompatible characteristics of sulfobetaine-containing brush polymers

    Year: 2012

    Journal: Macromolecular Research 2012, 20 (7) pp 746-753, 20121211

    Authors: Jin Chul Kim, Mihee Kim, Jungwoon Jung, Heesoo Kim, Ik Jung Kim, Jung Ran Kim and Moonhor Ree

    Organizations: Department of Chemistry, Division of Advanced Materials Science, Center for Electro-Photo Behaviors in Advanced Molecular Systems, Pohang Accelerator Laboratory, BK School of Molecular Science, and Polymer Research Institute, Pohang University of Science & Technology, Gyeongbuk, 790-784 Korea; Department of Microbiology, and Dongguk Medical Institute, Dongguk University College of Medicine, Gyeongbuk, 780-714 Korea; Department of Pathology, and Dongguk Medical Institute, Dongguk University College of Medicine, Gyeongbuk, 780-714 Korea

    A series of well-defined brush polymers, poly(oxy(11-(3-sulfonylpropyltrimethyl-glycinyl)undecylesterthiomethyl) ethylene-co-oxy(n-dodecylthio-methyl)ethylene)s (PECH-DMAPSm, where m is the mol% of the DMAPS [sulfobetaine] end group) were synthesized. The thermal properties and phase transitions of these polymers were investigated. The polymers were thermally stable up to 185 °C and were found to form favorably into multibilayer structures, always providing hydrophilic, zwitterionic sulfobetaine end groups at the film surface. Because of the presence of these sulfobetaine groups at the surface, the polymer films promoted HEp-2 cell adhesion and revealed biocompatibility in mice but significantly suppressed protein adsorption. These results collectively indicate that the sulfobetaine-containing brush polymers are suitable for use in biomedical applications, including medical devices and biosensors that require biocompatibility.