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    Cell Adhesion on Nanotextured Slippery Superhydrophobic Substrates

    Year: 2011

    Journal: Langmuir, 2011, 27 (8), pp 4914–4921, 20111221

    Authors: Rosa Di Mundo†, Marina Nardulli†, Antonella Milella†, Pietro Favia†‡§, Riccardo d’Agostino†‡§, and Roberto Gristina*‡

    Organizations: † Department of Chemistry, University of Bari, Via Orabona 4, 70126 Bari, Italy, ‡ Institute of Inorganic Methodologies and Plasmas IMIP-CNR, c/o University of Bari, Via Orabona 4, 70126 Bari, Italy, § Plasma Solution Srl, Spin Off of the University of Bari, Via Orabona 4, 70126 Bari, Italy

    In this work, the response of Saos2 cells to polymeric surfaces with different roughness/density of nanometric dots produced by a tailored plasma-etching process has been studied. Topographical features have been evaluated by atomic force microscopy, while wetting behavior, in terms of water−surface adhesion energy, has been evaluated by measurements of drop sliding angle. Saos2 cytocompatibility has been investigated by scanning electron microscopy, fluorescent microscopy, and optical microscopy. The similarity in outer chemical composition has allowed isolation of the impact of the topographical features on cellular behavior. The results indicate that Saos2 cells respond differently to surfaces with different nanoscale topographical features, clearly showing a certain inhibition in cell adhesion when the nanoscale is particularly small. This effect appears to be attenuated in surfaces with relatively bigger nanofeatures, though these express a more pronounced slippery/dry wetting character.