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    Characterization of self-assembled decyl bis phosphonate–Collagen layers on titanium by QCM -D and osteoblast-compatibility

    Year: 2011

    Journal: Applied Surface Science, Volume 257, Issue 22, 1 September 2011, Pages 9287-9292, 20110906

    Authors: Ni Y., Liu Z., Gao W., Qu S., Weng J., Feng B.

    Last authors: Bo Feng

    Organizations: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, 111 North Second Ring Road, Chengdu 610031, Sichuan, PR China

    Country: China

    Quartz crystal microbalance dissipation ( QCM -D) was used to monitor the layer by layer (LBL) self-assemble process of decyl bis phosphonate (DBP) and Collagen on titanium. The mass and viscoelastic properties of self-assembled layers were obtained using QCM -D. The stability of DBP and Collagen layer on titanium was tested to be very good. Osteoblasts cell culture was performed on LBL modified samples and that after BSA adsorption. The morphology of cells was observed by a scanning electron microscope (SEM). The total metabolic activity and differentiation of osteoblasts were evaluated by a metabolic assay and alkaline phosphatase (ALP) activity, respectively. These tests showed that osteoblasts have better activity, proliferation, and differentiation on Collagen terminated samples and BSA adsorbed samples.

    These results, along with the good biomineralization and protein adsorption abilities of Ti/DBP/Collagen surface (tested in our previous work), suggest titanium modified by this layer by layer technique has the potential application for medical implants.