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    Charge- and temperature-dependent interactions between anionic poly(N-isopropylacrylamide) polymers in solution and a cationic surfactant at the water/air interface

    Year: 2011

    Journal: Soft Matter, 2011, 7 (18), 8498-8507, 20131009

    Authors: Sondre Volden, Jan Genzer, Kaizheng Zhu, Marit-Helen G. Ese, Bo Nyström, Wilhelm R. Glomm

    Organizations: Ugelstad Laboratory, Department of Chemical Engineering, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, USA; Department of Chemistry, University of Oslo, P.O. Box 1033, Oslo, Norway; SINTEF Energy Research, Trondheim, Norway

    Due to their expanded coil to collapsed globule transition close to physiological temperatures, N-isopropylacrylamide (NIPAAM) polymers and derivatives thereof represent promising drug delivery vectors. Here, we report on the interaction between anionic PNIPAAM derivatives containing potassium 3-sulfopropylmethacrylate (SPMA) blocks of various sizes and a cationic lipid membrane mimic as a function of temperature, polymer charge density and molecular weight, by injection under a pre-compressed surfactant monolayer. The resulting film properties (including equilibria) were studied using surface pressure–area isotherms, Brewster angle microscopy, and interfacial 2D oscillatory rheology. Whereas mixed films of dioctadecyldimethylammonium bromide (DODAB) and an uncharged PNIPAAM homopolymer resulted in distinct polymer and surfactant domains, the anionic polyelectrolytes were found to ionically cross-link and contract the DODAB film. Film penetration, charge screening and surfactant film contraction were dependent on the molecular weight and size of the SPMA blocks on the polymers.