Year: 2011
Journal: Chem. Commun., 2012, 48, 191-193, 20111207
Authors: Liu P. 1 †, Zhang S. 2 †, Chen M-S 1, Liu Q 1, Wang C. 3, Wang C. 3, Li Y-M 1 *, Besenbacher F 2 *, Dong M. 2 *
Last authors: Mingdong Dong
Organizations: Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, China. E-mail: liym@mail.tsinghua.edu.cn; Fax: +86 10 6278 1695; Tel: +86 10 6279 6197 2 Interdisciplinary Nanoscience Center (iNANO) and Department of Physics and Astronomy, Aarhus University, DK-8000, Aarhus C, Denmark. E-mail: fbe@inano.au.dk; dong@inano.au.dk; Fax: +45 8942 3690; Tel: +45 8942 3702 3 National Center for Nanoscience and Technology, Beijing, 100190, China
Country: China, Denmark
The pathogenesis of type II diabetes can be linked to cosecreted hIAPP/insulin interacting with cell membranes. Here we investigate the nanostructures by co-assembling hIAPP and insulin on surfaces. By tuning the hIAPP/insulin ratio, atomic force microscopy reveals the resulting nanostructure morphology changes from fibrils to oligomers, to annular. Implications for in vivo studies are discussed.
