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    Complexation chemistry for tuning release from polymer coatings.

    Year: 2006

    Journal: J Phys Chem B Condens Matter Mater Surf Interfaces Biophys. 2006 Nov 2;110(43):21808-15., 20100827

    Authors: Fant C, Handa P, Nyden M.

    Last authors: Nyden M.

    Organizations: Cell and Molecular Biology/Biolpolymer Products AB, Goteborg University, Box 462, SE-405 30 Goteborg, Sweden, and Applied Surface Chemistry, Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-412 96, Goteborg, Sweden.

    Country: Sweden

    The strategy of metal ion complexation is employed to design a delivery system for an antifouling agent (AFA) in marine paints. A poly(1-vinylimidazole-co-methyl methacrylate) copolymer (PVM), together with Cu(2+) or Zn(2+) formed a PVM-M(2+) complex. The AFA, Medetomidine, was then coordinated into the complex. The coordination strength was investigated in solution by (1)H NMR and on solid surfaces by using the Quartz Crystal Microbalance with Dissipation monitoring technique (QCM-D) and Surface Plasmon Resonance (SPR). From the (1)H NMR experiments strong interactions were observed between Cu(2+) and the PVM-polymer and between Medetomidine and the PVM-Cu(2+) complex. From the QCM-D and SPR measurements it was shown that Cu(2+), compared to Zn(2+), exhibited a larger affinity for the PVM-copolymer surface that resulted in higher degree of swelling of the polymer film. Large amounts of Medetomidine were adsorbed to the PVM-Cu(2+) complex resulting in low desorption rates. However, the adsorbed amount of Medetomidine was lower to the Zn(2+) doped polymer and a higher desorption rate was observed. These results indicate the possibility of tuning the release of Medetomidine by altering the coordinating metal ion, which may prove to be favorable in a paint formulation.