Contact
    Start Publications Construction and Biofunction of 3-Dimensional Self-assembly ...
    ←  Publication Finder
    KSV NIMA

    Construction and Biofunction of 3-Dimensional Self-assembly Collagen Nanostructure on PLLA Substrate

    Year: 2010

    Journal: Chin. J. Chem., 2010, 28 (9), 1565-1574, 20131009

    Authors: Shouhong Xu, Aiping Liu, Xiaoxiao Lin, Honglai Liu, Masakastu Yonese

    Organizations: Key Laboratory for Advanced Materials and Department of Chemistry, East China University of Science and Technology, Shanghai 200032, China; Graduate School of Pharmaceutical Science, Nagoya City University, Japan

    A 3-dimensional and multi-layered network nanostructure of collagen assembled on the poly(L-lactic) acid (PLLA) substrate was reported. Collagen adsorption layers were prepared by dipping PLLA substrates into collagen solutions with various pH. The influences of adsorption interval, pH of collagen solutions and properties of PLLA substrate on the adsorption behavior of collagen were investigated by using atomic force microscopy and ellipsometry measurements. It was found that the multiple association degrees of collagen molecules in solution at a certain pH value seemed to play an important role in the adsorption process. The distinct adsorption behavior determined a specific 3-dimensional structure formed at the interface. Furthermore, calcium carbonate (CaCO3) can be biomimetically crystallized by the inducement of biomineralization on these collagen layers.