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    Controlled Protein Absorption and Cell Adhesion on Polymer-Brush-Grafted Poly(3,4-ethylenedioxythiophene) Films

    Year: 2013

    Journal: ACS Appl. Mater. Interfaces, 2013, 5 (11), pp 4536–4543, 20131003

    Authors: Haichao Zhao * 1, Bo Zhu 1, Shyh-Chyang Luo 1, Hsing-An Lin 1 2, Aiko Nakao 3, Yoshiro Yamashita 2, and Hsiao-hua Yu * 1

    Last authors: Hsiao-hua Yu

    Organizations: 1 Yu Initiative Research Unit, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan 2 Department of Electronic Chemistry, Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology 3 RNC Industrial Cooperation Team, RIKEN, Wako, Saitama 351-0198, Japan

    Country: Japan

    Tailoring the surface of biometallic implants with protein-resistant polymer brushes represents an efficient approach to improve the biocompability and mechanical compliance with soft human tissues. A general approach utilizing electropolymerization to form initiating group (-Br) containing poly(3,4-ethylenedioxythiophen)s (poly(EDOT)s) is described. After the conducting polymer is deposited, neutral poly((oligo(ethylene glycol) methacrylate), poly(OEGMA), and zwitterionic poly([2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide), poly(SBMA), brushes are grafted by surface-initiated atom transfer radical polymerization. Quartz crystal microbalance (QCM) experiments confirm protein resistance of poly(OEGMA) and poly(SBMA)-grafted poly(EDOT)s. The protein binding properties of the surface are modulated by the density of polymer brushes, which is controlled by the feed content of initiator-containing monomer (EDOT-Br) in the monomer mixture solution for electropolymerization. Furthermore, these polymer-grafted poly(EDOT)s also prevent cells to adhere on the surface.