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    Controlled Release from Model Blend Multilayer Films Containing Mixtures of Strong and Weak Polyelectrolytes

    Year: 2012

    Journal: Macromolecules, 2012, 45 (8), pp 3542–3549, 20120618

    Authors: Yeongseon Jang†, Bulent Akgun‡§, Hosub Kim†, Sushil Satija‡, and Kookheon Char*†

    Last authors: Kookheon Char

    Organizations: † The National Creative Research Initiative Center for Intelligent Hybrids, The WCU Program of Chemical Convergence for Energy & Environment, School of Chemical & Biological Engineering, Seoul National University, Seoul 151-744, Korea ‡ NIST Center for Neutron Research, NIST, Gaithersburg, Maryland 20899-6102, United States § Department of Materials Science and Engineering, University of Maryland, College Park, Maryland 20742, United States

    Country: Korea, South Korea, USA, US, United States, United States of America, America

    We have designed the controlled release platforms based on polyelectrolyte (PE) blend multilayer films to investigate the release mode and kinetics at the nanoscale level. The model blend multilayer films are composed of positively charged layers with weak polyelectrolytes (PEs) (linear poly(ethylenimine), LPEI) and negatively charged blend layers with mixtures of strong (poly(sodium 4-styrenesulfonic acid), PSS) and weak (poly(methacrylic acid), PMAA) PEs. The blend multilayer films ([LPEI/PSS:PMAA]n) with well-defined internal structure were prepared by the spin-assisted layer-by-layer (LbL) deposition method. Release properties of the multilayer films were systematically studied as a function of blend ratio by neutron reflectivity (NR), ellipsometer, AFM, FT-IR spectroscopy, and quartz crystal microbalance with dissipation (QCM-D). Since PSS strong PEs serve as robust skeletons within the multilayer films independent of external pH variation, the burst disruption of pure weak PE multilayer films was dramatically suppressed, and the release kinetics could be accurately controlled by simply changing the PSS content within the blend films. These release properties of blend multilayer films form the basis for designing the controlled release of target active materials from surfaces.