Year: 2012
Journal: J. Am. Chem. Soc., 2012, 134 (1), pp 83–86, 20120618
Authors: Johanna Davila†, Armelle Chassepot‡§, Johan Longo†, Fouzia Boulmedais† , Andreas Reisch , Benoît Frisch , Florent Meyer‡§, Jean-Claude Voegel‡§, Philippe J. Mésini†, Bernard Senger‡§, Marie-Hélène Metz-Boutigue‡§, Joseph Hemmerl釧, Philippe Lavalle‡§, Pierre Schaaf* , and Loïc Jierry†
Last authors: Loïc Jierry
Organizations: † Centre National de la Recherche Scientifique, Institut Charles Sadron, UPR 22, 67034 Strasbourg Cedex, France ‡ Institut National de la Santé et de la Recherche Médicale, INSERM Unité 977, 67085 Strasbourg Cedex, France § Université de Strasbourg, Faculté de Chirurgie Dentaire, 67000 Strasbourg, France International Center for Frontier Research in Chemistry, 67083 Strasbourg, France Laboratoire de Conception et Application de Molécules Bioactives, CNRS/Université de Strasbourg, UMR 7199, 67401 Illkirch Cedex, France
Country: France
Cell adhesion processes take place through mechanotransduction mechanisms where stretching of proteins results in biological responses. In this work, we present the first cyto-mechanoresponsive surface that mimics such behavior by becoming cell-adhesive through exhibition of arginine–glycine–aspartic acid (RGD) adhesion peptides under stretching. This mechanoresponsive surface is based on polyelectrolyte multilayer films built on a silicone sheet and where RGD-grafted polyelectrolytes are embedded under antifouling phosphorylcholine-grafted polyelectrolytes. The stretching of this film induces an increase in fibroblast cell viability and adhesion.
