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    Cytocompatible polyurethanes from fatty acids through covalent immobilization of collagen

    Year: 2013

    Journal: Reactive & Functional Polymers, 73, 690-697, 20130926

    Authors: Rodolfo J. González-Paz, Ana M. Ferreira, Clara Mattu, Francesca Boccafoschi, Gerard Lligadas, Juan C. Ronda, Marina Galià, Virginia Cádiz, Gianluca Ciardelli

    Organizations: Department of Analytical and Organic Chemistry, Rovira i Virgili University, Campus Sescelades, Marcel.lí Domingo s/n, 43007 Tarragona, Spain, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy, Department of Health Sciences, Università del Piemonte Orientale, Via Solaroli 17, Novara, Italy, CNR-IPCF UOS Pisa Via Moruzzi 1, 56124 Pisa, Italy

    Two different polyurethanes synthesized from two triols derived from undecenoic acid (PU1) and oleicacid (PU2) fatty acids were functionalised with Collagen type I via plasma treatment aimed at obtainingnovel biomaterials with improved biological properties. Scanning Electron Microscopy, X-ray photoelectronspectroscopy, optical microscopy, colorimetric titration methods and contact angle measurementsconfirmed the surface changes at each stage of treatment, both in terms of morphology and chemicalcomposition. The results for osteoblastic cells (MG63) cultured in vitro proved that PUs modified withcollagen had better cytocompatibility that the control PUs. In particular, PU2 displays highercytocompatibility.