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    Designing Hyaluronic Acid-Based Layer-by-Layer Capsules as a Carrier for Intracellular Drug Delivery

    Year: 2010

    Journal: Biomacromolecules, 2010, 11 (3), pp 713–720, 20100827

    Authors: Szarpak A. †, Cui D. †, Dubreuil F. †, De Geest B.G. ‡, De Cock L.J. ‡, Picart C. §, Auzely-Velty R. *†

    Last authors: Rachel Auzely-Velty

    Organizations: Centre de Recherches sur les Macromolecules Vegetales (CERMAV-CNRS), BP53, 38041 Grenoble cedex 9, France, Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium, Minatec, Grenoble Institute of Technology and LMGP, 3 parvis Louis Neel, F-38016 Grenoble Cedex, France

    Country: France

    Polyelectrolyte microcapsules were prepared by the layer-by-layer assembly of hyaluronic acid (HA) and a polycationic polymer, poly(allylamine) (PAH) or poly(lysine) (PLL). The influence of the polycationic partner on the morphology, stability, permeability properties, and enzymatic degradation of microcapsules was thoroughly analyzed. It was found that these properties could be tuned by shell cross-linking. Confocal microscopy studies of cellular uptake of the capsules showed that the polyelectrolyte shells remain stable outside the cells but readily break open once internalized by cells, suggesting their potential as carrier for intracellular drug delivery.