Contact
    Start Publications Development and Long-Term In Vivo Evaluation of a Biodegradable ...
    ←  Publication Finder
    Attension

    Development and Long-Term In Vivo Evaluation of a Biodegradable Urethane-Doped Polyester Elastomer

    Year: 2011

    Journal: Macromolecular Materials and Engineering 2011, 296 (12) pp 1149-1157, 20121211

    Authors: Jagannath Dey, Richard T. Tran, Jinhui Shen, Liping Tang, Jian Yang

    Organizations: Department of Bioengineering, The University of Texas at Arlington, Arlington, TX 76019, USA

    A detailed report on the development of CUPE polymers synthesized using diols with 4, 6, 8, 10, or 12 methylene units is presented with the aim of elucidating the influence of the diol component on the physical properties of the resulting material and assessing their long-term biological performance in vivo. Increasing the diol length leads to lower crosslinking densities, higher hydrophobicities, higher tensile strengths and elasticities, and slower polymer degradation. The choice of diol does not affect the overall cell/tissue compatibility both in vitro and in vivo. The diol component is thus established as an important parameter in controlling the structure/property relationships of the polymers, thereby increasing the choice of biodegradable elastomers for tissue engineering applications.