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    Differences in cytocompatibility and hemocompatibility between carbon nanotubes and nitrogen-doped carbon nanotubes

    Year: 2011

    Journal: Carbon 2011, 49 (9) pp 3125-3133, 20121211

    Authors: M.L. Zhao, D.J. Li, L. Yuan, Y.C. Yue, H. Liu, X. Sun

    Organizations: College of Physics and Electronic Information Science, Tianjin Normal University, Tianjin 300387, China; Department of Mechanical & Materials Engineering, University of Western Ontario, London, ON, Canada

    The cytocompatibility and hemocompatibility of multiwalled carbonnanotubes and N-doped multiwalled carbonnanotubes grown on carbon papers by chemical vapor deposition were investigated. These materials were characterized using contact-angle measurements, cell- and platelet-adhesion assays, and hemolytic-rate testing, revealing significant effects of nitrogen doping in carbonnanotubes. The results showed that mouse fibroblast cells and mouse adipose-derived stem cells cultured on N-doped multiwalled carbonnanotubes displayed the higher cell-adhesion strength, viability, proliferation, and stretching than those on multiwalled carbonnanotubes without N doping and carbon paper, indicating that N-doped multiwalled carbonnanotubes possessed good cytocompatibility. No toxicity reactions were observed during the culturing period. It also displayed the lowest hemolytic rate.