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    Differentially Instructive Extracellular Protein Micro-nets

    Year: 2014

    Journal: J. Am. Chem. Soc., 2014, 136 (22), pp 7889–7898, 20141006

    Authors: Nilofar Faruqui †, Angelo Bella †, Jascindra Ravi †,Santanu Ray †, Baptiste Lamarre †, and Maxim G. Ryadnov †‡

    Last authors: Maxim G. Ryadnov

    Organizations: † National Physical Laboratory, Hampton Road, Teddington TW11 0LW, U.K. ‡ School of Physics and Astronomy, University of Edinburgh, Edinburgh EH9 3JZ, U.K.

    Country: England, UK, United Kingdom

    An ability to construct biological matter from the molecule up holds promise for applications ranging from smart materials to integrated biophysical models for synthetic biology. Biomolecular self-assembly is an efficient strategy for biomaterial construction which can be programmed to support desired function. A challenge remains in replicating the strategy synthetically, that is at will, and differentially, that is for a specific function at a given length scale. Here we introduce a self-assembly topology enabling a net-like architectural mimetic of native extracellular matrices capable of differential responses to cell adhesion—enhanced mammalian cell attachment and proliferation, and enhanced resistance to bacterial colonization—at the native sub-millimeter length scales. The biological performance of such protein micro-nets directly correlates with their morphological and chemical properties, offering thus an application model for differential extracellular matrices.