Contact
    Start Publications Dynamic Topographical Control of Mesenchymal Stem Cells by ...
    ←  Publication Finder
    Attension

    Dynamic Topographical Control of Mesenchymal Stem Cells by Culture on Responsive Poly (ϵ-caprolactone) Surfaces

    Year: 2011

    Journal: Advanced materials 2011, 23, (29), pp 3278-3283, 20121211

    Authors: Duy M. Le, Karina Kulangara, Andrew F. Adler, Kam W. Leong, Valerie Sheares Ashby

    Organizations: Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA

    Poly(ɛ-caprolactone) (PCL) shape-memory polymer (SMP) microarrays are a novel means to investigate the effect of dynamic topography on human mesenchymal stem cell (hMSC) morphology. The synthesis and characterization of oligo-precursors and PCL networks is described. The PCL surfaces demonstrate excellent surface shape-memory properties, minimal cytotoxicity, and excellent control over hMSC morphology.