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    Effect of carrageenans of different chemical structures in biointerfaces: A Langmuir film study

    Year: 2013

    Journal: COLLOIDS AND SURFACES B-BIOINTERFACES, Vol. 111, p 530-535, 20150703

    Authors: Lopez, Ricardo F.; Nobre, Thatyane M.; Accardo, Camila de Melo; Pernambuco Filho, Paulo C.; Nader, Helena B.; Lopes, Carla C.; Caseli, Luciano

    Organizations: Univ Fed Sao Paulo, Inst Environm Chem & Phamaceut Sci, Diadema, SP, Brazil; Univ Sao Paulo, Sao Carlos Inst Phys, Sao Carlos, SP, Brazil; Univ Fed Sao Paulo, Dept Biochem, Sao Paulo, Brazil

    Carrageenans have unique properties in the pharmaceutical and food industries that involve interactions with lipid interfaces, which may be accessed if surface chemistry techniques are employed. The interaction between three different types of carrageenans with dipalmitoylphosphatidylcholine (DPPC) was investigated using Langmuir monolayers as biointerface models. With a combination of data on Surface Pressure-Area Isotherms and Polarization Modulation Infrared Reflection-Absorption Spectroscopy (PM-IRRAS), the effect of different fractions on DPPC monolayers was compared by considering the chemical and structural differences as well as the anticoagulant activity of each fraction. Thus, a model is proposed in which carrageenans can encompass interactions that are maximized due to geometrical adaptations on behalf of the interactions between polysaccharide sulfate groups and lipid polar heads. (C) 2013 Elsevier B.V. All rights reserved.