Contact
    Start Publications Effect of Microphase Separation on the Protein Resistance of a ...
    ←  Publication Finder
    QSense

    Effect of Microphase Separation on the Protein Resistance of a Polymeric Surface

    Year: 2009

    Journal: Langmuir, 2009, 25 (16), pp 9467–9472, 20100827

    Authors: Ma C., Hou Y., Liu S., Zhang G.*

    Last authors: Guangzhao Zhang

    Organizations: Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemical Physics, University of Science and Technology of China, Hefei 230026, China

    Country: China

    Segmented polyurethanes (PUs) containing poly(ethylene glycol) (PEG), poly(propylene glycol), or poly(dimethylsiloxane) soft segments have been prepared by two-step condensation polymerization. Atom force microscopy observation in air and solution indicates that the segmented PU forms a microphase separation on the surface. By use of quartz crystal microbalance with dissipation and surface plasmon resonance, we have investigated the adsorption of fibrinogen, bovine serum albumin, and lysozyme on a surface constructed by such a PU in aqueous solution in real time. Our results reveal that the protein resistance of the PUs arises from the hydrated PEG segments instead of microphase separation.