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    Efficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics: An animal study in rabbits

    Year: 2013

    Journal: ACTA BIOMATERIALIA, Vol. 9, p 4815-4825, 20150703

    Authors: Lensing, Rebecca; Bleich, Andre; Smoczek, Anna; Glage, Silke; Ehlert, Nina; Luessenhop, Tammo; Behrens, Peter; Mueller, Peter Paul; Kietzmann, Manfred; Stieve, Martin

    Organizations: Hannover Med Sch, Dept Otolaryngol, D-30625 Hannover, Germany; Hannover Med Sch, Inst Lab Anim Sci, D-30625 Hannover, Germany; Hannover Med Sch, Cent Anim Facil, D-30625 Hannover, Germany; Leibniz Univ Hannover, Inst Inorgan Chem, D-30167 Hannover, Germany; Helmholtz Ctr Infect Res, D-38124 Braunschweig, Germany; Univ Vet Med Hannover, Dept Pharmacol Toxicol & Pharm, D-30559 Hannover, Germany

    Nanoporous silica layers are able to host molecules and release them over a certain period of time. These local drug delivery systems for antibiotics could be a new approach in the treatment of chronic otitis media. The aim of this study was to examine the efficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics in vivo. Pseudomonas aeruginosa was inoculated into the middle ear of rabbits to induce an otitis media. The control group received coated Bioveriell implants without antibiotics. Coated prostheses with loaded ciprofloxacin were implanted into the middle ears of the study group. After 1 week, the rabbits were sacrificed. The clinical examination as well as the microbiological and histological examinations of organs and middle ear irrigation revealed clear differences between the two groups. P. aeruginosa was detected in every middle ear of the control group and was almost completely eliminated in the study group. Organ examinations revealed the presence of P. aeruginosa in the control group and a prevention of a bacterial spread in the study group. The nanoporous silica layer as antibiotic delivery system showed convincing efficacy in induced pseudomonal otitis media in the rabbit. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.