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    Electrochemically Stimulated Release from Liposomes Embedded in a Polyelectrolyte Multilayer

    Year: 2011

    Journal: Advanced Functional Materials, Volume 21, Issue 9, pages 1666–1672, May 10, 2011, 20110526

    Authors: Graf N. 1, Albertini F. 1, Petit T. 1, Reimhult E. 2, Vörös J. 1, Zambelli T. 1

    Last authors: Tomaso Zambelli

    Organizations: 1 Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, University and ETH Zürich, Gloriastrasse 35, 8092 Zürich, Switzerland 2 Institut für Nanobiotechnologie (NBT), Muthgasse 11/II, A-1190 Wien, Austria

    Country: Switzerland, Austria

    Triggered release of an entrapped dye from vesicles embedded in a polyelectrolyte multilayer (PEM), as a consequence of the electrochemically induced local pH change in the vicinity of the electrode, is reported. The PEM was deposited on an indium tin oxide (ITO) electrode wherein lipid vesicles filled with a fluorescent dye were embedded. The use of vesicles with a strong negative charge and the polyelectrolyte species of the PEM matrix with a polycation as topmost layer enabled the generation of a stable layer of liposomes in the PEM.