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    Electrostatically driven interaction of silica-supported lipid bilayer nanoplatforms and a nerve growth factor-mimicking peptide

    Year: 2013

    Journal: Soft Matter, 2013,9, 4648-4654, 20130630

    Authors: Alessio Travaglia a, Cristina Satriano a, Maria Laura Giuffrida b, Diego La Mendola c, Enrico Rampazzo d, Luca Prodi d, Enrico Rizzarelli a b

    Last authors: Enrico Rizzarelli

    Organizations: a Department of Chemical Sciences, University of Catania, viale Andrea Doria, 6, 95125 Catania, Italy E-mail: csatriano@unict.it ; Fax: +39 095 580138 ; Tel: +39 095 738 5136 b Institute of Biostructures and Bioimages, Catania National Council of Research (CNR), viale Andrea Doria, 6, 95125 Catania, Italy c Department of Pharmacy, University of Pisa, via Bonanno Pisano 6, Pisa, Italy d “G. Ciamician” Department of Chemistry, University of Bologna, Via Selmi 2, 40126 Bologna, Italy

    Country: Italy

    The interaction between lipid vesicles and NGF(1–14) peptide, mimicking nerve growth factor, was addressed to fabricate peptide-associated supported lipid bilayers (SLBs). According to a model of predominant electrostatic interactions, zwitterionic and anionic lipid vesicles were used to optimize the peptide association with the lipid membranes. Both planar silica and core–shell nanoparticles (NPs) were used as polar hydrophilic substrates to form the SLBs functionalized with the NGF peptide. The hybrid biointerface was scrutinized by a multitechnique approach with QCM-D, FRAP and fluorescence spectroscopy in terms of self-assembling kinetics, lipid lateral diffusion, and energy transfer processes in the SLB-wrapped silica NPs dye-doped in the core. The response of neuronal cells to the NGF(1–14)-SLBs highlighted their promising application as a drug delivery nanoplatform for ageing-related diseases.