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    Formation and characterization of three-component-sorbitan monoester surfactant, oil and water-creams

    Year: 2004

    Journal: International Journal of Pharmaceutics 269 (2004) 227-239, 20111221

    Authors: Mirka Korhonen , Jouni Hirvonen , Leena Peltonen , Osmo Antikainen , Laura Yrjänäinen , Jouko Yliruusi

    Organizations: a Pharmaceutical Production, Orion Corporation Orion Pharma, P.O. Box 425, FIN-20101 Turku, Finland b Department of Pharmacy, Pharmaceutical Technology Division, University of Helsinki, P.O. Box 56, FIN-00014 Helsinki, Finland c Pharmaceutical Development, Orion Corporation Orion Pharma, P.O. Box 425, FIN-20101 Turku, Finland

    The effect of molecular structure of four sorbitan monoester surfactants (sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate and sorbitan monooleate) on the formation of simple three-component creams is presented. Interfacial properties of the surfactants were determined using a du Nouy tensiometer and rheological properties of selected creams with oscillation stress sweep, creep recovery and viscosity tests. Depending on the composition, sorbitan monolaurate and sorbitan monooleate formed both o/w creams and w/o creams, while sorbitan monopalmitate and sorbitan monostearate formed only o/w creams. Sorbitan monostearate and sorbitan monopalmitate had the smallest cmc and Acmc values and they were the most effective surfactants in lowering the interfacial tension. These surfactants formed the most stable and elastic creams with clear linear viscoelastic regions and small compliance values. Sorbitan monolaurate and sorbitan monooleate formed viscous creams without elastic properties.