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    Formation of supramolecular systems via directed Nucleoside–Lipid recognition

    Year: 2012

    Journal: Journal of Colloid and Interface Science, 2012, 377 (1), 122-130, 20131009

    Authors: Nada Taib, Ahissan Aimé, Louis Moreau, Michel Camplo, Said Houmadi, Bernard Desbat, Michel Laguerre, Mark W. Grinstaff, Isabelle Bestel, Philippe Barthélémy

    Organizations: Université de Bordeaux, Bordeaux F-33076, France; INSERM U869, Bordeaux F-33076, France; Université de Bordeaux, IECB-CBMN UMR 5248 CNRS, 2 rue Robert Escarpit, 33607 Pessac, France; Centre Interdisciplinaire des Nanomatériaux de Marseille CINaM, UPR-CNRS 3118, Université Aix-Marseille II, Luminy, case 913, 13288 Marseille cedex 09, France; Department of Biomedical Engineering, Metcalf Center for Science and Engineering, Boston University, Boston, MA 02215, USA

    We report the synthesis of a new series of Ketal Nucleoside Lipids (KNLs) featuring saturated hydrophobic double chains and either adenosine or uridine as nucleosides (KNLA and KNLU, respectively). Physicochemical studies (differential scanning calorimetry, small angle X ray scattering, transmission electronic microscopy, atomic force microscopy, Langmuir isotherm, infrared spectroscopy) show that the KNLs form hydrogels below the main phase transition temperature (Tm), whereas fluid lamellar phases are obtained above Tm. Mixing complementary KNLs affords a new stable Combined Supramolecular Systems (CSSs) due to complementary A-U recognition. Molecular modeling calculations of the bilayers in a fluid state exhibit a merging of the bilayers partially due to base–base interactions.