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    Functional Nanogels as Platforms for Imparting Antibacterial, Antibiofilm, and Antiadhesion Activities to Stainless Steel

    Year: 2012

    Journal: Advanced Functional Materials Volume 22, Issue 24, pages 5271–5282, December 19, 2012, 20130119

    Authors: Emilie Faure1, Céline Falentin-Daudré 1, Tiziana Svaldo Lanero 2, Christelle Vreuls 3, Germaine Zocchi 3, Cécile Van De Weerdt 3, Joseph Martial 3, Christine Jérôme 1, Anne-Sophie Duwez 2, Christophe Detrembleur 1*

    Last authors: Christophe Detrembleur

    Organizations: . 1
Center for Education and Research on Macromolecules, University of Liège, B6, Sart Tilman, 4000 Liège, Belgium . 2
Nanochemistry and Molecular Systems, University of Liège, B6, Sart-Tilman, 4000 Liège, Belgium . 3
Laboratoire de Biologie Moléculaire et de Génie Génétique, GIGA-Research, CHU, B34, Sart Tilman, 4000 Liège, Belgium

    Country: Belgium

    In this work, long-term antibacterial, antiadhesion, and antibiofilm activities are afforded to industrial stainless steel surfaces following a green and bio-inspired strategy. Starting from catechol bearing synthetic polymers, the film cross-linking and the grafting of active (bio)molecules are possible under environmentally friendly conditions (in aqueous media and at room temperature). A bio-inspired polyelectrolyte, a polycation-bearing catechol, is used as the film-anchoring polymer while a poly(methacrylamide)-bearing quinone groups serves as the cross-linking agent in combination with a polymer bearing primary amine groups. The amine/quinone reaction is exploited to prepare stable solutions of nanogels in water at room temperature that can be easily deposited to stainless steel. This coating provides quinone-functionalized surfaces that are then used to covalently anchor active (bio)molecules (antibiofilm enzyme and antiadhesion polymer) through thiol/quinone reactions.