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    Head Group Influence on Lipid Interactions With a Polyhydroxyalkanoate Biopolymer

    Year: 2012

    Journal: Macromol. Chem. Phys., 2012, 213 (18), 1922-1932, 20131009

    Authors: Agnieszka Jagoda, Manfred Zinn, Wolfgang Meier, Katarzyna Kita-Tokarczyk

    Organizations: Department of Chemistry, University of Basel, 4056 Basel, Switzerland; Bioprocesses and Biomaterials, Institute of Life Technologies, University of Applied Sciences Western Switzerland (HES-SO Valais), 1950 Sion, Switzerland

    Poly([R]-3-hydroxy-10-undecenoate) (PHUE) is a biodegradable/biocompatible polyester from polyhydroxyalkanoates (PHAs) family, used in biomedical applications. PHA's introduction to the body may have implications on cell membrane stability—this motivates studies of interactions between PHAs and phospholipids, main membrane constituents. Interaction analysis in PHUE monolayers with two phospholipids (different hydrophilic groups), phosphatidylserine (DOPS), and phosphatidylethanolamine (DOPE), shows that repulsive interactions between PHUE and DOPS and attractive between PHUE and DOPE resulted from different lipid headgroup size and orientation at the air–water interface (PE, parallel to the interface, attracted PHUE via hydrogen bonds, ion–dipole, and dipole–dipole interactions).