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    Highly-Branched Poly(N-isopropylacrylamide) as a Component in Poly(dopamine) Films

    Year: 2013

    Journal: J. Phys. Chem. B, 2013, 117 (36), pp 10504–10512, 20131001

    Authors: Yan Zhang 1 2, Boon M. Teo 2, Almar Postma 3, Francesca Ercole 4, Ryosuke Ogaki 2, Meifang Zhu *1, and Brigitte Städler *2

    Last authors: Brigitte Städler

    Organizations: 1 State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Material Science and Engineering, Donghua University, Shanghai 201620, People’s Republic of China 2 iNANO Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark 3 Ian Wark Laboratory, CSIRO Materials Science and Engineering, Bayview Avenue, Clayton, Victoria 3168, Australia 4 Department of Materials Engineering, Monash University, Clayton, Victoria 3800, Australia

    Country: China, Denmark, Australia

    Mixed one-step poly(dopamine) (PDA)/highly branched poly(N-isopropylacrylamide) (pNiPAAm) coatings have been assembled and characterized by X-ray photoelectron spectroscopy (XPS), UV–vis spectroscopy, atomic force microscopy, and quartz crystal microbalance with dissipation monitoring (QCM-D) depending on the deposition temperature below and above the lower critical solution temperature (LCST) of the pNiPAAm. Mixed films were confirmed. The protein adsorption at 24 °C was found to be reduced with increasing amount of pNiPAAm in the mixed coatings, while there was no difference observed for proteins deposition at 39 °C. Further, the ability of these mixed coatings in comparison to the pure PDA and pNiPAAm films to serve as capping layer for surface-immobilized zwitterionic or positively charged liposomes has been assessed by QCM-D. The adhesion of hepatocytes, macrophages, and myoblast to these liposomes-containing hybrid coatings and the uptake of fluorescent lipids from the surface by the adhering cells depending on the capping layers were compared. The latter aspect was found to be dependent on the used capping layer and the type of liposome as carrier for the fluorescent lipid, with the highest uptake found for positive liposomes and pure pNiPAAm as capping layer. Taken together, the assembled hybrid coatings have the potential to be used as functional coatings toward surface-mediated drug delivery.