Highly sensitive recognition of cancer cells by electrochemical biosensor based on the interface of gold nanoparticles/polylactide nanocomposites

The efficient diagnosis and therapy of cancers have been the hot topics in the clinic and biomedical areas. In this study, we have developed a new strategy for the fast and high sensitiverecognition of the drug-sensitive leukemia K562/B.W. cells and drug-resistant leukemia K562/ADM cells by combining the nanocompositesinterface of the goldnanoparticles/polylactide nanofibers (Au/PLA) with the electrochemical detection. Our observations demonstrate that the Au/PLA nanocomposites modified electrode could provide a much more hydrophilic interface for the rapid and high selective identification of leukemia cancercells. It is evident that different types of leukemia cells could be readily distinguished on the Au/PLA nanocomposites modified indium tin oxide (ITO) electrode, which have the promising application to be adopted as a significant way to detect and identify various cancercells and advance the clinical diagnosis and monitoring of tumors with the aim of successful chemotherapy of human cancers.