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    Human micro-vascular endothelial cell seeding on Cr-DLC thin films for mechanical heart valve applications

    Year: 2006

    Journal: Thin Solid Films, Volume 515, Issue 1, 25 September 2006, Pages 59-65, 20111221

    Authors: N. Ali, Y. Kousar, T.I. Okpalugo, V. Singh, M. Pease, A.A. Ogwu, J. Gracio, E. Titus, E.I. Meletis and M.J. Jackson

    Organizations: Centre for Mechanical Technology and Automation, University of Aveiro, Portugal, Northern Ireland Bio-Engineering Centre, NIBEC, University of Ulster, UK, Center for Advanced Microstructures and Devices, Louisiana State University, Baton Rouge, LA 70806, USA, Thin Film Centre, University of Paisley, Scotland, UK, Materials Science and Engineering, The University of Texas at Arlington, TX, USA, Department of Mechanical Engineering, University of Purdue, USA

    In this investigation, chromium modified diamond-like-carbon (Cr-DLC) films were studied for potential applications in mechanical heart valves. Three Cr- DLC samples were prepared using a magnetron sputtering technique employing an intensified plasma assisted processing (IPAP) system. The three samples consisted of the following Cr content: 1 at.%, 5 at.% and 10 at.%. The biological response of human micro-vascular endothelial cells (HMV-EC) seeded on Cr-DLC films was evaluated in terms of initial cell attachment and growth. The Cr-DLC films were characterized using Raman spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), secondary ion mass spectroscopy (SIMS) and by the contact angle technique. Endothelial cell adhesion and growth was found to be affected by changing the Cr content of Cr-DLC films.